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According to Alazzeh et al

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Mild, short-lived reactions can include soreness at the injection site, a brief flushing sensation, mild bruising, or, very rarely, mild nausea

GHK-Cu's copper complex can be destabilized by very low pH and by direct oxidizing or reducing agents

Another preclinical study using presymptomatic and symptomatic SOD1 G93A transgenic mice revealed an association between the accumulation of ceramides and cholesterol esters in the spinal cords of ALS patients and OS, thus highlighting the pivotal role of OS in inducing an alteration in the metabolism of sphingolipids metabolism which mediates MN death in ALS [112]